M9434
Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat
clone 14, tissue culture supernatant
Synonym(s):
Anti-MBP
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About This Item
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biological source
rat
Quality Level
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
14, monoclonal
contains
0.09% sodium azide
species reactivity
horse, chicken, human
technique(s)
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
isotype
IgG
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MBP(4155)
General description
Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.
Specificity
Recognizes amino acids 36-50 of myelin basic protein.
Immunogen
bovine myelin basic protein.
Biochem/physiol Actions
Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.
Preparation Note
Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the proteasome led us to attempt to compensate or mimic its positive charge to inhibit
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