I4902
Anti-Interferon-α/β Receptor 1 antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-IFN-α/β R1
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0.1 MG
6 740,00 kr
6 740,00 kr
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0.1 MG
6 740,00 kr
About This Item
6 740,00 kr
Please contact Customer Service for Availability
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: suitable (1-10μg/106 cells)
western blot: 0.1-1 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IFNAR1(3454)
General description
Interferon-α/β Receptor 1 is a dimeric, disulfide-linked protein that binds human interferons α and β. This receptor also interacts with Tyr kinase JAK1, and thereby regulates cellular signaling across the membranes . Anti-Interferon-α/β Receptor 1 is specific for recombinant human IFN-α/β R1 and does not react with recombinant human IFN-γ RI and IFN-γ RII.
Immunogen
recombinant human IFN-α/β R1 extracellular domain expressed in Sf21 insect cells.
Application
Anti-Interferon-α/β Receptor 1 antibody is suitable for usein flow cytometry (1-10μg/106 cells) and western blot (0.1-1 μg/mL). Theantibody may also be used for immunoblotting (approx. 135kDa) and indirectimmunofluorescence (using appropriate secondary antibodies).
Physical form
0.1-1 μg/mL Recombinant Human IFN-α/β R1, HeLa humancervical epithelial carcinoma cell line, K562 human chronic myelogenousleukemia cell line.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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S N Constantinescu et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(20), 9602-9606 (1994-09-27)
A previously cloned cDNA encodes one subunit of the human interferon alpha/beta receptor (IFN alpha R), denoted IFN alpha R1. To study the expression and signaling of IFN alpha R1, we used monoclonal antibodies (mAbs) generated against the baculovirus-expressed ectodomain
D Novick et al.
Cell, 77(3), 391-400 (1994-05-06)
We describe a universal ligand-binding receptor for human interferons alpha and interferon beta (type I IFNs). A soluble 40 kDa IFN-alpha/beta receptor (p40) that blocks the activity of type I IFNs was purified from urine and sequenced. Antibodies raised against
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