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H5520

Sigma-Aldrich

17α-Hydroxyprogesterone hexanoate

≥98%

Synonym(s):

17α-Hydroxyprogesterone caproate

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About This Item

Empirical Formula (Hill Notation):
C27H40O4
CAS Number:
630-56-8
Molecular Weight:
428.60
EC Number:
211-138-8
MDL number:
MFCD00072134
UNSPSC Code:
12352200
PubChem Substance ID:
24895697

Assay

≥98%

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCCCC)C(C)=O

InChI

1S/C27H40O4/c1-5-6-7-8-24(30)31-27(18(2)28)16-13-23-21-10-9-19-17-20(29)11-14-25(19,3)22(21)12-15-26(23,27)4/h17,21-23H,5-16H2,1-4H3/t21-,22+,23+,25+,26+,27+/m1/s1

InChI key

DOMWKUIIPQCAJU-LJHIYBGHSA-N

Gene Information

human ... PGR(5241)

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Biochem/physiol Actions

Shows significant reduction of pre-term delivery by mothers with a history of premature delivery, with no detectable harm to the infant.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
073H1027

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Faris Mujezinovic et al.
The Cochrane database of systematic reviews, 8(8), CD008678-CD008678 (2012-08-17)
Currently, the techniques for amniocentesis and chorionic villus sampling (CVS) tend to be described in local and national guidelines, but certain aspects, including the choice of instruments, is predominantly based upon the operator's personal preference. A survey of practice in
Mary Hines et al.
Clinical drug investigation, 33(3), 223-227 (2013-02-16)
Intramuscular 17 α-hydroxyprogesterone caproate (Makena(®)), a synthetic progestin, is indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of a singleton spontaneous preterm birth. Makena(®) reduces the risk of preterm birth
Shringi Sharma et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(2), 296-304 (2012-11-07)
Little information is available in the literature regarding the expression and activity of transporters in fetal human liver or cultured cells. A synthetic progesterone structural analog, 17α-hydroxyprogesterone caproate (17-OHPC), is used in the prevention of spontaneous abortion in women with
John M O'Brien
American journal of perinatology, 29(9), 665-672 (2012-07-10)
The safety of supplemental progestin therapy during pregnancy reflects whether an agent exclusively promotes or potentially inhibits progestational cellular functions and whether treatment incites a metabolic derangement or other pathophysiology to initiate rare untoward events. No safety signal has been
Julie Romero et al.
American journal of obstetrics and gynecology, 207(1), 51-51 (2012-05-19)
The objective of the study was to estimate the predictive value of cervical length (CL) and fetal fibronectin (fFN) in patients being treated with 17-alpha-hydroxyprogesterone caproate (17P). This was a retrospective cohort of 176 patients with a prior spontaneous preterm
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