G6264

Guanosine

BioReagent, suitable for cell culture

• Synonym(s): 9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
• Empirical Formula (Hill Notation): C₁₀H₁₃N₅O₅
• CAS Number: 118-00-3
• Molecular Weight: 283.24
• Beilstein: 625911
• EC Number: 204-227-8
• MDL number: MFCD00010182
• UNSPSC Code: 12352205
• PubChem Substance ID: 24895251
• NACRES: NA.75

Properties

• biological source: synthetic
• product line: BioReagent
• Assay: ≥98%
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 250 °C (dec.) (lit.)
• solubility: 0.05 M acetic acid: 1 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
• InChI key: NYHBQMYGNKIUIF-UUOKFMHZSA-N

Description

Application

Guanosine has been used:

• as a ribonucleoside component of the basal medium to study its effects on Bacillus mojavensis′s anaerobic growth
• as a component of the Dulbecco′s modified Eagle medium (DMEM) to culture mouse-derived embryonic stem cells
• as a component of the nucleoside solution to culture chicken embryonic stem cells

Biochem/physiol Actions

Guanosine is a purine nucleoside that exhibits important functions in cell metabolism. It has also shown neuroprotective and neurotrophic effects in glial cells, hippocampal neurons, and pheochromocytoma cells by inducing proliferation and differentiation and also exerting anti-apoptotic effects. Guanosine acts as a therapeutic agent against several neuropathologies. It exerts its effects against sepsis-induced cognitive impairment, hepatic encephalopathy, lipopolysaccharide (LPS)-induced inflammation, ischemic injury, and azide-induced oxidative damage. Guanosine is suitable for use in cell culture applications as a precursor of guanosine monophosphate (GMP), guanosine diphosphate (GDP), guanosine triphosphate (GTP), and cyclic GMP (cGMP).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves