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Key Documents

D0670

Sigma-Aldrich

Dihydroouabain

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About This Item

Empirical Formula (Hill Notation):
C29H46O12
CAS Number:
Molecular Weight:
586.67
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

SMILES string

[H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]4(C)[C@H](CC[C@]24O)[C@H]5COC(=O)C5)O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O

InChI

1S/C29H46O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h13-19,21-25,30-32,34-38H,3-12H2,1-2H3/t13-,14?,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1

InChI key

ZTFGOPUOTATSAL-CFVDWFIMSA-N

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Biochem/physiol Actions

Cardiac glycoside; an inhibitor of the sodium-potassium pump.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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N A Delamere et al.
Investigative ophthalmology & visual science, 39(5), 763-768 (1998-04-16)
In a previous study, an increase in Na,K-ATPase alpha 2 expression was detected in the epithelium of porcine lenses exposed to amphotericin B, an ionophore that also increases lens sodium and stimulates active sodium transport. The purpose of the present
Akiyuki Taruno et al.
Neuroscience research, 72(2), 117-128 (2011-11-22)
A glutamatergic end-bulb synapse in the avian nucleus magnocellularis relays temporal sound information from the auditory nerve. Here, we show that presynaptic Na(+)/K(+)-ATPase (NKA) activity at this synapse contributes to the maintenance of the readily releasable pool (RRP) of vesicles
Raimondo D'Ambrosio et al.
Journal of neurophysiology, 87(1), 87-102 (2002-01-11)
Little information is available on the specific roles of different cellular mechanisms involved in extracellular K(+) homeostasis during neuronal activity in situ. These studies have been hampered by the lack of an adequate experimental paradigm able to separate K(+)-buffering activity
Isamu Ito et al.
Investigative ophthalmology & visual science, 47(2), 683-692 (2006-01-25)
To evaluate the effect of acute exposure to high glucose on myogenic tone and reactivity of the rat ophthalmic artery and to compare the observations with that in ophthalmic artery from a diabetic rat model. Ophthalmic arteries from Sprague-Dawley rats
J Gao et al.
Biophysical journal, 89(3), 1700-1709 (2005-08-30)
There are well-documented differences in ion channel activity and action potential shape between epicardial (EPI), midmyocardial (MID), and endocardial (ENDO) ventricular myocytes. The purpose of this study was to determine if differences exist in Na/K pump activity. The whole cell

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