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C0984
Creatine Kinase MB Fraction from human heart
≥70% (SDS-PAGE), liquid
Synonym(s):
CK MB Fraction
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100 μG
6 030,00 kr
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100 μG
6 030,00 kr
About This Item
Recommended Products
biological source
human heart
Quality Level
Assay
≥70% (SDS-PAGE)
form
liquid
concentration
≥0.5 mg/mL
technique(s)
IR spectroscopy: suitable
suitability
suitable for tissue
application(s)
pharmaceutical
storage temp.
−20°C
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General description
Research area: Cell Signaling
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.[1]
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.[1]
Application
Creatine Kinase MB Fraction from human heart has been used:
Biochem/physiol Actions
Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate.[1] The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury.[1] It is regarded as a “gold standard” for myocardial infarction diagnosis.[1] The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels.[5] CK-MB levels may also be elevated in chronic renal failure.[6]
Components
Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Annals of clinical and laboratory science, 32(1), 44-49 (2002-02-19)
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin
Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin
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J E Adams et al.
Clinical chemistry, 40(7 Pt 1), 1291-1295 (1994-07-01)
Although measurement of cardiac troponin I (cTnI) is, in some situations, more specific for detection of cardiac injury than is measurement of the MB isoenzyme of creatine kinase (MBCK), its sensitivity and specificity relative to MBCK for detection of myocardial
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What does the MB stand for in Product C0984, Creatine Kinase MB Fraction from human heart?
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Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain).
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