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T3812

Tetracaine

Name: Tetracaine
Brand: SIAL

meets USP testing specifications

Synonym(s):

4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₄N₂O₂

CAS Number:

94-24-6

Molecular Weight:

264.36

EC Number:

202-316-6

MDL number:

MFCD00053787

UNSPSC Code:

12352202

PubChem Substance ID:

24900174

NACRES:

NA.21

Agency

USP/NF
meets USP testing specifications

Quality Level

200

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

SMILES string

CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3

InChI key

GKCBAIGFKIBETG-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Application

Topical ophthalmic anesthetic; used for spinal anesthesia

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca²⁺ from sarcoplasmic reticulum.

Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H317,H351

Precautionary Statements

P201 - P280 - P301 + P310 + P330 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Howard Bregman et al.

Journal of medicinal chemistry, 54(13), 4427-4445 (2011-06-04)

Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Herein, we report structure-activity relationships for a novel series of 2,4-diaminotriazines that inhibit hNav1.7. Optimization

A continuous flow method for estimation of drug release rates from emulsion formulations.

Lotta Salmela et al.

International journal of pharmaceutics, 472(1-2), 276-281 (2014-06-20)

We present a continuous-flow method that allows the release of drugs from submicron colloidal carriers to be estimated on a millisecond timescale. The technique is applied to the study of release of a model drug (tetracaine) from lipid emulsions, and

Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children.

Anna Taddio et al.

The Annals of pharmacotherapy, 36(4), 687-692 (2002-03-29)

To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children. Systematic review was performed (MEDLINE1990-June 2001) of all studies comparing the efficacy of these 2 modalities of pain relief in children undergoing painful cutaneous procedures. Search

Gain and phase of perceived virtual rotation evoked by electrical vestibular stimuli.

Ryan M Peters et al.

Journal of neurophysiology, 114(1), 264-273 (2015-05-01)

Galvanic vestibular stimulation (GVS) evokes a perception of rotation; however, very few quantitative data exist on the matter. We performed psychophysical experiments on virtual rotations experienced when binaural bipolar electrical stimulation is applied over the mastoids. We also performed analogous

High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists.

Yveline Henchoz et al.

Journal of medicinal chemistry, 51(3), 396-399 (2008-01-15)

Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds

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