SMB00975

Bisdesethylchloroquine Hydrochloride

• Synonym(s): Bisdesethyl chloroquine hydrochloride, Didesethylchloroquine hydrochloride
• Empirical Formula (Hill Notation): C₁₄H₁₈ClN₃ · xHCl
• Molecular Weight: 263.77 (free base basis)
• MDL number: MFCD00871854
• NACRES: NA.77

Properties

• Assay: ≥95% (HPLC)
• Quality Level: 200
• form: solid
• storage temp.: 2-8°C

Description

General description

Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug.

Application

Metabolomics research

Other Notes

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Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable