92822

Picrylsulfonic acid solution

1 M in H₂O

• Synonym(s): 2,4,6-Trinitrobenzenesulfonic acid solution, TNBS
• Empirical Formula (Hill Notation): C₆H₃N₃O₉S
• CAS Number: 2508-19-2
• Molecular Weight: 293.17
• Beilstein: 572358
• MDL number: MFCD00064382
• UNSPSC Code: 12352005
• PubChem Substance ID: 329770176
• NACRES: NA.25

Properties

• form: liquid
• Quality Level: 200
• concentration: 1 M in H₂O
• density: 1.14 g/mL at 20 °C
• ε (extinction coefficient): ≤0.85 at 340 nm
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OS(=O)(=O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
• InChI: 1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)
• InChI key: NHJVRSWLHSJWIN-UHFFFAOYSA-N

Description

Application

Hydrophilic modifying reagent. Derivatives with amino compounds can be regenerated with hydrazine.

Picrylsulfonic acid (2,4,6-Trinitrobenzenesulfonic acid solution, TNBS) may be used in studies on the mechanisms of intracellular pH regulation. TNBS is used to induce inflammatory bowel disease (IBD)/colonic inflammation for studies on its mechanism and treatment.

Caution

decomposes when stored at temperatures ≥0°C with precipitate formation (picric acid)

Other Notes

Sales restrictions may apply

Safety Information

• Pictograms: GHS02,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H207,H302,H314,H317
• Precautionary Statements: P210 - P212 - P230 - P233 - P280 - P303 + P361 + P353 - P305 + P351 + P338 - P370 + P380 + P375 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Desen. Expl. 3 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves