67667

Kynurenic acid

analytical standard

• Synonym(s): KYNA, 4-Hydroxyquinoline-2-carboxylic acid
• Empirical Formula (Hill Notation): C₁₀H₇NO₃
• CAS Number: 492-27-3
• Molecular Weight: 189.17
• Beilstein: 147451
• EC Number: 207-751-5
• MDL number: MFCD00006753
• UNSPSC Code: 41116107

Properties

• grade: analytical standard
• Assay: ≥98.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• mp: 275 °C (dec.) (lit.)
• application(s): clinical testing
• SMILES string: OC(=O)c1cc(O)c2ccccc2n1
• InChI: 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
• InChI key: HCZHHEIFKROPDY-UHFFFAOYSA-N

Description

General description

Kynurenic acid, a tryptophan metabolite, is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors. This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain. Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia. Its anticonvulsant and neuroprotective properties are experimentally reported.

Application

Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples, food and honeybee products using high-performance liquid chromatography with fluorescence detection.

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable