Archives of biochemistry and biophysics, 321(1), 153-159 (1995-08-01)
The potential of fumarate reductase as a therapeutic target against the human pathogen Helicobacter pylori was investigated by studying the cytotoxicity of morantel, oxantel, and thiabendazole, known to inhibit the enzyme in parasitic worms. Nuclear magnetic resonance spectroscopy was employed
Journal of the American Chemical Society, 127(45), 15771-15777 (2005-11-10)
It is now known that the untreated discharge of pharmaceuticals into the environment can impact human health and development and lead to increased drug resistance in biota. Here, we present the first direct interface-specific studies that address the mobility of
Acid phosphatase (AP) activity was detected in 24 h culture media from adult Heligmosomoides polygyrus. Female and male excretion/secretion products showed similar specific activity. For both, the AP had a pH optimum of 4.0 and was inhibited by sodium fluoride
Journal of veterinary medicine. B, Infectious diseases and veterinary public health, 47(1), 1-8 (2000-04-26)
The secretion of acetylcholinesterase (AChE) by female and male Heligmosomoides polygyrus was studied in different in vitro culture media. AChE secretion was increased in the presence of fetal calf serum or bovine serum albumin (BSA). In the absence of crowding
Two homomer-forming nicotinic acetylcholine receptor subunits with 47% identity in their amino acid sequences were employed to compare the actions of cholinergic anthelmintics and ivermectin on expressed vertebrate and nematode nicotinic receptors of known molecular composition. Voltage-clamp electrophysiology was used
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