SCC193
HSC-3 Human Tongue Squamous Carcinoma Cell Line
Human
Synonym(s):
HSC 3, HSC3
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About This Item
UNSPSC Code:
41106514
eCl@ss:
32011203
NACRES:
NA.81
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Product Name
HSC-3 Human Tongue Squamous Carcinoma Cell Line, HSC-3 human tongue squamous carcinoma cell line is a suitable model for the study of metastatic squamous cell carcinoma.
biological source
human
technique(s)
cell culture | mammalian: suitable
General description
Athymic nude mice xenografted with human carcinoma have been used as an in vivo model of tumor invasion and metastasis. Most reports indicate that metastasis of human epithelial tumors inoculated subcutaneously into nude mice is rather rare. HSC-3 is a human oral squamous carcinoma cell line that forms metastatic foci in the draining lymph nodes when subcutaneously transplanted into nude mice [1]. Conditioned media from HSC-3 has been shown to promote angiogenesis, HSC-3 cells having markedly elevated levels of growth factor secretion [2]. The highly aggressive characteristics of this cell line have made HSC-3 a highly cited model for the study of metastatic squamous cell carcinoma.
Source:
The HSC-3 cell line was established from tumors of metastatic lymph nodes originated in tongue squamous cell carcinomas of a 63-year old male patient. Epithelial cells that migrated and proliferated were collected and subcultured from fresh explanted tumor tissues [1].
Source:
The HSC-3 cell line was established from tumors of metastatic lymph nodes originated in tongue squamous cell carcinomas of a 63-year old male patient. Epithelial cells that migrated and proliferated were collected and subcultured from fresh explanted tumor tissues [1].
Squamous cell carcinoma is the most common malignant neoplasm found in the oral cavity and cervical metastases are frequently observed [2]. Suppression of regional lymph node metastases is one of the most significant factors affecting favorable prognosis of squamous cell carcinoma [2]. Experimental models of lymphogenous metastasis analogous to progression of human oral carcinoma are needed to provide an opportunity to investigate metastatic mechanisms.
Cell Line Description
Cancer Cells
Application
HSC-3 human tongue squamous carcinoma cell line is a suitable model for the study of metastatic squamous cell carcinoma.
Research Category
Cancer
Cancer
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact [email protected].
Quality
• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
• Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Storage and Stability
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Sofia K Georgiou-Siafis et al.
Biomedicines, 10(11) (2022-11-12)
Chimeric antigen receptor (CAR) immunotherapy includes the genetic modification of immune cells to carry such a receptor and, thus, recognize cancer cell surface antigens. Viral transfection is currently the preferred method, but it carries the risk of off-target mutagenicity. Other
Y Michi et al.
Oral oncology, 36(1), 81-88 (2000-07-13)
Angiogenesis is an important phenomenon for the growth and metastasis of solid tumors. The present study examined the characterization of angiogenic factors produced by human oral squamous cell carcinoma (oral SCC) cell lines established from lymph node metastatic tumors and
F Momose et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 18(7), 391-395 (1989-08-01)
Variant sublines LMF3, LMF4 and LMF5 with high metastatic potential were established from a human oral squamous carcinoma cell line HSC-3. These sublines metastasized to the draining lymph nodes after subcutaneous inoculation into nude mice. They were obtained by sequential
Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug-activating suicide gene therapies.
Xu, et al.
Experimental and Therapeutic Medicine, 25, 92-92 (2023)
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