ABN117

Anti-PDE4D3 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): cAMP-specific 3′,5′-cyclic phosphodiesterase 4D, DPDE3, PDE43
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: rat, mouse, rhesus macaque
• species reactivity (predicted by homology): human (immunogen homology), rhesus monkey (based on 100% sequence homology)
• technique(s): western blot: suitable
• NCBI accession no.: NP_006194
• UniProt accession no.: Q08499
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... PDE4D(5144)

Description

General description

Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides. PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation. PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects. PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke.

Specificity

This antibody recognizes PDE4D3 at the N-terminus.

Immunogen

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of human PDE4D3.

Application

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This Anti-PDE4D3 Antibody is validated for use in WB for the detection of PDE4D3.

Quality

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected PDE4D3 on 10 µg of mouse brain membrane tissue lysate.

Target description

~95 kDa observed. UniProt describes 12 isoforms produced by alternative splicing.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse brain membrane tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable