A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM).
A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
Biochem/physiol Actions
Cell permeable: yes
Primary Target Protein kinase c-Raf
Product competes with ATP.
Reversible: yes
Target IC50: 70 nM against protein kinase c-Raf
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Other Notes
Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559.
Legal Information
Sold under license of PCT Application W098/22,103.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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