An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC50 = 4, 19 800 and >30 000 nM at GPR55, CB2 and CB1 receptors respectively). Producing robust anti-inflammatory actions by activating PPARα (EC50 = 3 µM).
Biochem/physiol Actions
Primary Target GPR55 receptor
Warning
Toxicity: Standard Handling (A)
Preparation Note
Slight warming is required for complete solubilization.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Griffin, G., et al. 2000. J. Pharmacol. Exp. Ther.292, 886.
Lambert, D., et al. 2001. Epilepsia.42, 321. Lambert, D., et al. 2002. Curr. Med. Chem.9, 663. Lo Verme, J., et al. 2005. Life Sci.77, 1685. Re, G., et al. 2005. Vet. J.173, 21. Ryberg, R., et al. 2007. Br. J. Pharmacol.152, 1092.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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