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About This Item
Linear Formula:
F2C6H3SO2NH2
CAS Number:
Molecular Weight:
193.17
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
97%
mp
157-161 °C (lit.)
SMILES string
NS(=O)(=O)c1cc(F)cc(F)c1
InChI
1S/C6H5F2NO2S/c7-4-1-5(8)3-6(2-4)12(9,10)11/h1-3H,(H2,9,10,11)
InChI key
MKQPOVUFDWKPNO-UHFFFAOYSA-N
General description
3,5-Difluorobenzenesulfonamide is a fluorinated benzenesulfonamide. It is a CA (carbonic anhydrase) inhibitor that binds to human carbonic anhydrase I by forming a 1:1 complex.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Fluorine NMR studies of the human carbonic anhydrase-3, 5-difluorobenzenesulfonamide complex
Veenstra DL and Gerig JT
Magnetic Resonance in Chemistry, 36(S1), S169-S178 (1998)
Virginija Dudutienė et al.
Bioorganic & medicinal chemistry, 21(7), 2093-2106 (2013-02-12)
A series of 4-substituted-2,3,5,6-tetrafluorobenezenesulfonamides were synthesized and their binding potencies as inhibitors of recombinant human carbonic anhydrase isozymes I, II, VII, XII, and XIII were determined by the thermal shift assay, isothermal titration calorimetry, and stop-flow CO2 hydration assay. All
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