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SAB4200073

Sigma-Aldrich

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

Synonym(s):

Anti-C polypeptide, protein-glutamine-gamma-glutamyltransferase, Anti-G-alpha-h, Anti-TG2, Anti-TGC, Anti-TGM2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~78 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1.5 mg/mL

technique(s)

immunohistochemistry: 5-10 μg/mL using formalin-fixed and paraffin embedded human placenta
immunoprecipitation (IP): 15-30 μg using human placenta extracts
indirect immunofluorescence: 2-4 μg/mL using U87 cells
western blot: 1-2 μg/mL using U87 cell extracts

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TGM2(7052)

General description

Tranglutaminase-2 (also known as TGM2, TG2), is a widely expressed, multifunctional protein.

Application

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence
  • immunohistochemistry

Biochem/physiol Actions

Tranglutaminase-2 possesses enzymatic and GTPase activities, involved in multiple cell functions, including cell adhesion and cell signaling. TGM2 functions as a Ca2+-dependent enzyme capable of crosslinking both cytosolic and extracellular matrix proteins by catalyzing the formation of isopeptide bonds between lysine and glutamine residues. TGM2 is involved in the regulation of cell-matrix adhesion, cytoskeletal structure, cell migration and apoptosis. It is activated in response to tissue injury and plays an important role in wound healing and immune response. TGM2 is a major autoantigen in celiac disease and altered TGM2 expression or activity may be associated with Alzheimer′s disease, arteriosclerosis, type-2 diabetes and cancer metastasis in numerous forms of cancer.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A role for tissue transglutaminase in stabilization of membrane-cytoskeletal particles shed from the human placenta
Robinson NJ, et al.
Biology of Reproduction, 77(4), 648-657 (2007)
Cellular Functions of Tissue Transglutaminase
Nurminskaya MV, et al.
International Review of Cell and Molecular Biology (2012)
The role of tissue transglutaminase in cell-matrix interactions
Zemskov EA, et al.
Frontiers in Bioscience, 1057-1076 (2006)
New insight into transglutaminase 2 and link to neurodegenerative diseases
Min B and Chung KC
Bmb Reports, 51(1), 5-5 (2018)
Biological functionalities of transglutaminase 2 and the possibility of its compensation by other members of the transglutaminase family
Odii BO and Coussons P
TheScientificWorldJournal (2014)

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