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Ketanserin (+)-tartrate salt

Name: Ketanserin (+)-tartrate salt
Brand: SIGMA

≥97%, 5-HT2 serotonin receptor antagonist, solid

Synonym(s):

3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt, R 41468 (+)-tartrate salt

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₂FN₃O₃ · C₄H₆O₆

CAS Number:

83846-83-7

Molecular Weight:

545.51

NACRES:

NA.77

PubChem Substance ID:

24278121

UNSPSC Code:

12352202

EC Number:

281-062-8

MDL number:

MFCD00084651

Assay:

≥97%

Form:

solid

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Properties

Product Name

Ketanserin (+)-tartrate salt, ≥97%, solid

Quality Segment

100

assay

≥97%

form

solid

color

white

solubility

ethanol: 3 mg/mL, DMSO: 52 mg/mL (lit.)(lit.), 0.1 M HCl: 6 mg/mL (lit.)(lit.)

storage temp.

2-8°C

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4ccccc4C3=O

InChI

1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1

InChI key

KMTLTEVOQLMYRS-LREBCSMRSA-N

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Description

Application

Ketanserin (+)-tartrate salt has been used:

as a 5HT2A antagonist in Krebs-Henseleit buffer solution
for hormonal treatment to study the effects of exogenous manipulation of different hormonal systems in interaction with parasite infection on client′s behavior
to study the behavioural changes of incision pain rats

Biochem/physiol Actions

Selective 5-HT₂ serotonin receptor antagonist.

Selective 5-HT₂ serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.

Ketanserin stimulates collagen synthesis and is involved in wound healing.

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This Item	SML1236	C221	V2264
Sigma-Aldrich S006 Ketanserin (+)-tartrate salt	Sigma-Aldrich SML1236 (−)-Nicotine hydrogen tartrate salt	Sigma-Aldrich C221 Carboxy-PTIO potassium salt	Sigma-Aldrich V2264 Vinorelbine ditartrate salt hydrate
form solid	form powder	form powder	form powder
assay ≥97%	assay ≥98% (HPLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C
solubility ethanol: 3 mg/mL, 0.1 M HCl: 6 mg/mL (lit.)(lit.), DMSO: 52 mg/mL (lit.)(lit.)	solubility H₂O: 20 mg/mL, clear	solubility H₂O: 100 mg/mL, DMSO: soluble (lit.)(lit.), methanol: soluble (lit.)(lit.)	solubility H₂O: 10 mg/mL
color white	color white to beige	color -	color off-white

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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