Skip to Content
Merck
All Photos(1)

Key Documents

O5632

Sigma-Aldrich

Linoleic acid, conjugated methyl ester

Synonym(s):

CLA methyl ester, Octadecadienoic acid, conjugated, methyl ester

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

biological source

plant (safflower)

Quality Level

Assay

≥99% (GC)

form

liquid

technique(s)

GC/MS: suitable
HPLC: suitable

impurities

≤1% Linoleic acid methyl ester

functional group

carboxylic acid
ester

lipid type

omega FAs

shipped in

ambient

storage temp.

−20°C

Related Categories

General description

Conjugated linoleic acid (CLA) describes the positional and geometric isomers of C18:2 fatty acids (FA) with a conjugated double bond. cis-9, trans-11 CLA are considered as the major isomers of CLA, based on in vitro experiments and animal studies in milk. The major source of CLA in human diet is the ruminant fat.

Application

Linoleic acid, conjugated methyl ester (CLA) has been used as a standard for the determination of isomers of CLA in milk samples by high performance liquid chromatography (HPLC), gas chromatography-mass spectrometry. It has also been used in the production of sn-1,3 diacyl glycerol.

Biochem/physiol Actions

Conjugated linoleic acid (CLA) isomers as supplements inhibit the growth of numerous human cancer cell lines. It also possesses immunostimulant properties, prevents diabetes and reduces atherosclerosis.

Other Notes

A mixture of cis- and trans-9,11- and -10,12-octadecadienoic acid methyl esters. Isomer ratio may vary from lot to lot.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Rahmat Ababakri et al.
Journal of animal science and technology, 63(3), 475-490 (2021-07-01)
An experiment was conducted to determine the effects of two levels of rumen undegradable protein (RUP) without or with whole or extruded flaxseed on milk yield, milk component, milk fatty acids (FAs) profile and plasma metabolites in transition ewes. Three
Examination of the persistency of milk fatty acid composition responses to fish oil and sunflower oil in the diet of dairy cows
Shingfield KJ, et al.
Journal of Dairy Science, 89(2), 714-732 (2006)
Enzymatic synthesis of structured triacylglycerols containing CLA isomers starting from sn-1, 3-diacylglycerols
Maurelli S, et al.
Journal of the American Oil Chemists' Society, 86(2), 127-133 (2009)
Effect of incremental levels of sunflower-seed oil in the diet on ruminal lipid metabolism in lactating cows
Shingfield KJ, et al.
The British Journal of Nutrition, 99(5), 971-983 (2008)
P G Toral et al.
Journal of dairy science, 101(7), 6109-6121 (2018-05-01)
A great deal of uncertainty still exists about intermediate metabolites and pathways explaining the biohydrogenation (BH) of 20- and 22-carbon polyunsaturated fatty acids (PUFA). Therefore, this study was conducted to provide further insight into the ruminal metabolism of 20:5 n-3

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service