K2015

K-252a

From Nonomuraea longicatena, >98%, tyrosine kinase receptor inhibitor, solution

• Synonym(s): SF 2370
• Empirical Formula (Hill Notation): C₂₇H₂₁N₃O₅
• CAS Number: 99533-80-9
• Molecular Weight: 467.47
• NACRES: NA.77
• PubChem Substance ID: 329817131
• UNSPSC Code: 12352200
• EC Number: 200-664-3
• MDL number: MFCD00161522
• Assay: >98%
• Form: solution

Properties

• Product Name: K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%
• biological source: Nonomuraea longicatena
• Quality Segment: 200
• assay: >98%
• form: solution
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• InChI key: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Gene Information: human ... NTRK1(4914) ; rat ... Prkca(24680)

Description

Biochem/physiol Actions

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Features and Benefits

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physical form

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)