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I2633

Sigma-Aldrich

Cardiogreen

Powder

Synonym(s):

Foxgreen, IC Green, Indocyanine green

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About This Item

Empirical Formula (Hill Notation):
C43H47N2NaO6S2
CAS Number:
3599-32-4
Molecular Weight:
774.96
Beilstein:
4115884
EC Number:
222-751-5
MDL number:
MFCD00013078
UNSPSC Code:
12171500
PubChem Substance ID:
24895979
NACRES:
NA.47

product name

Cardiogreen, polymethine dye

form

powder

composition

Dye content, ≥75%

color

green to very dark green

solubility

water: 0.01 g/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CC1(C)/C(=C\C=C\C=C\C=C\C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c5ccc6ccccc6c15

InChI

1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1

InChI key

MOFVSTNWEDAEEK-UHFFFAOYSA-M

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General description

Cardiogreen is a negatively charged polymethine dye that forms noncovalent fluorescent complexes with proteins. This "pseudofluorogenic" property has been utilized for protein determination by capillary electrophoresis with diode laser-induced fluorescence detection.

Application

Cardiogreen has been used to resolve several labeled proteins including: human serum albumin, ribonuclease A, transferrin, and cytochrome c.
Cardiogreen has been used as an intraocular capsular stain. It has been used in the dye-dilution method for cardiac output.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

solubility: 0.01g in 10mL H2O : green to very dark green

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E M McCorquodale et al.
Electrophoresis, 22(12), 2403-2408 (2001-08-25)
Indocyanine green (ICG)--a negatively charged, polymethine dye--can interact noncovalently with proteins to form fluorescent complexes, with excitation and emission maxima near 780 and 820 nm, respectively. This behavior was realized utilizing either a 100 mM phosphate buffer or a 25
Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.
Irwin D et al.
American Journal of Respiratory Cell and Molecular Biology, 42, 200-200 (2010)
Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.
Huang AS et al.
Translational vision science & technology, 5, 5-5 (2016)
Toshiki Endo et al.
Journal of neurosurgery. Spine, 18(5), 443-449 (2013-03-12)
The characteristics and efficacy of indocyanine green (ICG) videoangiography in cavernous malformation (CM) have not been fully elucidated. The purpose of this paper is to examine the potential utility of ICG videoangiography in the surgical treatment of intramedullary CMs. The
Jun Shibasaki et al.
The Journal of pediatrics, 164(5), 1116-1120 (2014-02-13)
To investigate the use of indocyanine green (ICG) lymphography in the diagnosis and assessment of the severity of lymphatic dysfunction in infants and neonates with congenital lymphatic pleural effusion and ascites. We performed ICG lymphography on 10 neonates and infants
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