E1253

Estriol

synthetic (organic), ≥97%, immunomodulatory , powder

• Synonym(s): 1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene
• Empirical Formula (Hill Notation): C₁₈H₂₄O₃
• CAS Number: 50-27-1
• Molecular Weight: 288.38
• NACRES: NA.77
• PubChem Substance ID: 24894396
• UNSPSC Code: 51111800
• EC Number: 200-022-2
• MDL number: MFCD00003691
• Beilstein/REAXYS Number: 2508172
• Assay: ≥97%
• Form: powder

Properties

• Product Name: Estriol, ≥97%
• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥97%
• form: powder
• mp: 280-282 °C (lit.)
• solubility: pyridine: 50 mg/mL, clear, colorless to faintly brownish-yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O
• InChI: 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
• InChI key: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• Gene Information: human ... SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208)

Description

Application

Estriol has been used as a sex hormone to determine its binding constants to insulin (INS), the insulin receptor (IR), and INS-like peptides derived from the IR.

Biochem/physiol Actions

Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and estrone are produced by the placenta during pregnancy. These are also the primary estrogens produced by adipose tissue in men and post-menopausal women. Estriol may exhibit immunomodulatory benefits against various diseases such as autoimmune, inflammatory, and neurodegenerative conditions.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD,H362
• pcodes: P201 - P202 - P260 - P263 - P264 - P308 + P313
• Hazard Classifications: Carc. 2 - Lact. - Repr. 1A
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges