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D7909

Sigma-Aldrich

Dicyclomine hydrochloride

≥99% (TLC), powder

Synonym(s):

2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride, [1,1-Bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H35NO2 · HCl
CAS Number:
67-92-5
Molecular Weight:
345.95
EC Number:
200-671-1
MDL number:
MFCD00079158
UNSPSC Code:
41116107
PubChem Substance ID:
24278385
NACRES:
NA.77

Assay

≥99% (TLC)

form

powder

color

off-white

solubility

H2O: 50 mg/mL

SMILES string

CCN(CCOC(C1(C2CCCCC2)CCCCC1)=O)CC.[Cl]

InChI

1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H

InChI key

GUBNMFJOJGDCEL-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Surabi Veeraragavan et al.
Psychopharmacology, 217(1), 143-151 (2011-04-14)
Muscarinic acetylcholine receptors (mAChR) are G protein-coupled receptors, widely expressed in the CNS. Electrophysiological and molecular studies have provided evidence for overactive M1 receptor signaling in the fragile X knockout (Fmr1 KO) mouse model, suggesting the involvement of the M1
Christopher D Cox et al.
Journal of neurotrauma, 25(11), 1355-1365 (2008-12-09)
Recent studies indicate that alphaII-spectrin breakdown products (SBDPs) have utility as biological markers of traumatic brain injury (TBI). However, the utility of SBDP biomarkers for detecting effects of therapeutic interventions has not been explored. Acetylcholine plays a role in pathological
Z W Jiang et al.
Brain research, 852(1), 37-44 (2000-02-08)
The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively
P Grillner et al.
Neuroscience, 91(2), 557-565 (1999-06-12)
The effects of carbachol (0.01-30 microM) and muscarine (10-30 microM) on the excitatory synaptic potentials were studied using conventional intracellular recordings from dopaminergic neurons in rat mesencephalic slices. Both muscarinic agonists reversibly reduced the excitatory synaptic potentials, evoked by local
Susan J Bartko et al.
Psychopharmacology, 214(2), 537-548 (2010-11-19)
Performance on the Cambridge Neuropsychological Test Automated Battery touchscreen paired-associates learning (PAL) test is predictive of Alzheimer's disease and impaired in schizophrenia and chronic drug users. An automated computer touchscreen PAL task for rats has been previously established. A pharmacologically
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