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Merck

D7625

2′-Deoxycytidine 5′-monophosphate sodium salt

≥98%, microbial (fermentation), powder

Synonym(s):

Deoxycytidylic acid, dCMP

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About This Item

Linear Formula:
C9H12N3O7PNa2
CAS Number:
Molecular Weight:
351.16
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
235-995-2
MDL number:
Assay:
≥98%
Biological source:
microbial (fermentation)
Form:
powder
Storage temp.:
−20°C
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Product Name

2′-Deoxycytidine 5′-monophosphate sodium salt, Sigma Grade, ≥98%

biological source

microbial (fermentation)

Quality Level

grade

Sigma Grade

assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)N(C=C1)C2CC(O)C(COP(O)(O)=O)O2

InChI

1S/C9H14N3O7P.Na.H/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17);;

InChI key

BLEUYVBRJBDVEH-UHFFFAOYSA-N

Application

2′-Deoxycytidine 5-monophosphate (dCMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form dCDP which upon phosphorylation to dCTP supports DNA and RNA biosynthesis.
2′-Deoxycytidine 5′-monophosphate sodium salt has been used:
  • in nucleoside stability studies in human renal cell carcinoma (RCC) cell line SN12C
  • in the cell proliferation studies of human intestinal Caco-2 cell line and peripheral blood mononuclear cells (PBMCs)
  • as a ligand in dsDNA activation-induced cytidine deaminase crystallization


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Rafael Andrade Caceres et al.
Journal of molecular modeling, 14(5), 427-434 (2008-03-18)
Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP and CMP to, respectively, UDP and
AID recognizes structured DNA for class switch recombination
Qiao Q, et al.
Molecular Cell, 67(3), 361-373 (2017)
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
Zauri M, et al.
Nature, 524(7563), 114-114 (2015)



Global Trade Item Number

SKUGTIN
D7625-100MG04061833007006
D7625-1G04061826690604