D0899

Diazepam

≥98% (TLC), powder, GABAA receptor ligand

• Synonym(s): 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one, Ro 5-2807
• Empirical Formula (Hill Notation): C₁₆H₁₃ClN₂O
• CAS Number: 439-14-5
• Molecular Weight: 284.74
• NACRES: NA.77
• PubChem Substance ID: 24893306
• UNSPSC Code: 12352200
• EC Number: 207-122-5
• MDL number: MFCD00057323
• Form: powder
• Quality level: 200

Properties

• Product Name: Diazepam,
• form: powder
• Quality Level: 200
• drug control: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL, DMF: soluble, H₂O: slightly soluble, ethanol: soluble
• originator: Roche
• SMILES string: CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
• InChI key: AAOVKJBEBIDNHE-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879) ; rat ... Gabra1(29705), Gabra2(29706)

Description

Application

Diazepam has been used:

• as an anxiolyte in pilocarpine protocol.
• in multi-electrode array (MEA) technology
• as a marker for human serum albumin

Biochem/physiol Actions

Anxiolytic; ligand for the GABA_A receptor benzodiazepine modulatory site.

Diazepam is a benzodiazepine anxiolytic agent. It serves as a prototype ligand for the GABAA receptor benzodiazepine modulatory site.

Diazepam is often used as a sedative. Its metabolism involves cytochrome P450 (CYP) 2C19 and 3A4. Diazepam has immediate action upon administration.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Safety Information

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301 + H311,H410
• pcodes: P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves