The cyclin B1 (CCNB1) gene is mapped to human chromosome 5q13.2. The gene codes for a 62kDa protein containing a classical cyclin box domain. CCNB1 shuttles between the nucleus and cytoplasm until prophase begins. It is a member of the cyclin family and is expressed at low levels in normal cells.
Immunogen
recombinant hamster cyclin B1
Application
Anti-cyclin B1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Cyclin B1 (CCNB1) and cyclin-dependent kinase 1 (CDK1) complex play a crucial role in regulation of mitosis. Elevated expression of the gene has been observed in various types of human cancers including breast, lung, colon, prostate and head and neck cancers. Thus, this protein can be considered as a potent target for cancer vaccines. In addition, CCNB1 also serves as a prognostic biomarker for estrogen-receptor-positive (ER+) breast cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Virus infection disturbs cyclin expression, leading to cell cycle arrest in the unicellular marine algae Emiliania huxleyi and Chrysochromulina ericina
Liu J, et al.
African Journal of Microbiology Research, 5, 1801-1807 (2011)
Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer
Fang Y, et al.
Cancer Biology & Therapy, 15, 1268-1279 (2014)
CCNB1 is a prognostic biomarker for ER+ breast cancer
Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (e.g., MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives to microtubule-targeting antimitotic agents (e.g., paclitaxel) to circumvent resistance and side effects associated with their use. They can be classified
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
