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C7519

Sigma-Aldrich

Choline bicarbonate

~80% in H2O

Synonym(s):

2-Hydroxyethyl)trimethylammonium bicarbonate

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About This Item

Linear Formula:
C5H14NO · HCO3
CAS Number:
78-73-9
Molecular Weight:
165.19
MDL number:
MFCD00031689
UNSPSC Code:
50501514
PubChem Substance ID:
24892967
NACRES:
NA.25

form

liquid

concentration

~80% in H2O

density

1.17 g/mL at 25 °C (lit.)

lipid type

phospholipids

storage temp.

2-8°C

SMILES string

OC([O-])=O.C[N+](C)(C)CCO

InChI

1S/C5H14NO.CH2O3/c1-6(2,3)4-5-7;2-1(3)4/h7H,4-5H2,1-3H3;(H2,2,3,4)/q+1;/p-1

InChI key

DQKGOGJIOHUEGK-UHFFFAOYSA-M

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Application

Choline, a water soluble essential nutrient, is used by the body to make phosphatidylcholine phosphatides and neurotransmitter such as acetylcholine. Choline is used to study a wide range of biological processes from stem cell development to neurological disease studies. Also, An alkaline intermediate useful for preparing salts.

Biochem/physiol Actions

Acyl group acceptor

Substrates

Choline acetyltransferase substrate

Other Notes

Note: The bicarbonate converts to the carbonate with release of CO2 on aging.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hussain Mohamad Awwad et al.
Clinical biochemistry, 45(18), 1548-1553 (2012-08-28)
Choline is an essential nutrient that is necessary for cell membrane synthesis and phospholipid metabolism and functions as an important methyl donor. Multiple roles for choline in cancer development have been suggested. Choline can affect DNA methylation and lead to
Karen D Corbin et al.
Progress in molecular biology and translational science, 108, 159-177 (2012-06-05)
Advances in nutrigenetics and nutrigenomics have been instrumental in demonstrating that nutrient requirements vary among individuals. This is exemplified by studies of the nutrient choline, in which gender, single-nucleotide polymorphisms, estrogen status, and gut microbiome composition have been shown to
Erica C Silva et al.
Research in veterinary science, 135, 42-58 (2021-01-14)
In the present research work, we propose a new antimicrobial treatment for pyoderma via cutaneous permeation of bacteriophage particles conveyed in a hydroxyethylcellulose (HEC) gel integrating ionic liquid as a permeation enhancer. Ionic liquids are highly viscous fluids constituted exclusively
Eden E L Tanner et al.
Journal of controlled release : official journal of the Controlled Release Society, 286, 137-144 (2018-07-22)
Transdermal delivery of pharmaceuticals using ionic liquids and deep eutectic solvents (DES) has attracted significant interest due to the inherent tunability of the molecules and their capacity to transport large molecules across the skin. Several key properties of DESs including
Diana Gómora-Herrera et al.
Applied spectroscopy, 72(4), 562-572 (2017-12-09)
The effects exerted by the adsorption of vapors of a non-polar compound (deuterated benzene) and a polar compound (water) on the surface of Ottawa sand and a sample of reservoir sand (Channel), which was previously impregnated with silicon oil or
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