04273

Sodium phosphate dibasic dodecahydrate

meets analytical specification of Ph. Eur., BP, E339, 98.5-102.5% (T)

• Synonym(s): sec-Sodium phosphate, Disodium hydrogen phosphate dodecahydrate, Disodium phosphate, di-Sodium hydrogen phosphate dodecahydrate
• Linear Formula: Na₂HPO₄ · 12H₂O
• CAS Number: 10039-32-4
• Molecular Weight: 358.14
• EC Number: 231-448-7
• MDL number: MFCD00149181
• UNSPSC Code: 12161700
• PubChem Substance ID: 329747907
• NACRES: NA.25

Properties

• Agency: meets analytical specifications of BP; meets analytical specifications of Ph. Eur.
• Quality Level: 200
• Assay: 98.5-102.5% (T)
• form: crystals
• quality: meets analytical specification of Ph. Eur., BP, E339
• impurities: reducing matter, complies; residual solvents, complies; ≤0.001% heavy metals (as Pb); ≤1.0% NaH₂PO₄; 57-61% water (Karl Fischer)
• loss: 57-61% loss on drying
• pH: 8.4-9.6 (20 °C, 1%)
• anion traces: chloride (Cl^-): ≤10 mg/kg; fluoride (F^-): ≤10 mg/kg; sulfate (SO₄^2-): ≤100 mg/kg
• cation traces: As: ≤1 mg/kg; Cd: ≤1 mg/kg; Cu: ≤20 mg/kg; Fe: ≤10 mg/kg; Hg: ≤1 mg/kg; K: ≤50 mg/kg; Pb: ≤4 mg/kg; Zn: ≤10 mg/kg
• suitability: complies for appearance of solution
• SMILES string: O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O
• InChI: 1S/2Na.H3O4P.12H2O/c;;1-5(2,3)4;;;;;;;;;;;;/h;;(H3,1,2,3,4);12*1H2/q2*+1;;;;;;;;;;;;;/p-2
• InChI key: DGLRDKLJZLEJCY-UHFFFAOYSA-L

Description

Application

• Study of the Influence of Alkalizing Components on Matrix Pellets Prepared by Extrusion/Spheronization: This publication examines the effects of sodium phosphate dibasic dodecahydrate as an alkalizing agent in matrix pellets, showcasing its application in improving the physicochemical properties of pellets, which are crucial for controlled drug delivery systems (Hamedelniel EI, Bajdik J, Kasa P Jr, Pintye-Hodi K, 2012).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable