Skip to Content
Merck
All Photos(1)

Key Documents

219419

Sigma-Aldrich

Cathepsin Inhibitor III

The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin Inhibitor III, Z-FG-NHO-BzOME

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C27H27N3O7
Molecular Weight:
505.52
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

>90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

ethanol: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

10-30°C

General description

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1 x 104 M-1 sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1 sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1 sec-1), and papain (k2/Ki = 1 x 103 M-1 sec-1).
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1.0 x 104 M-1sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1sec-1), and papain (k2/Ki = 1.0 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Biochem/physiol Actions

Cell permeable: no
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Phe-Gly-NHO-Bz-pOMe

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service