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850338P

Avanti

MAPCHO™-14

n-tetradecylphosphocholine, powder

Synonym(s):

TPC; Fos-Choline-14; FOS14; FC-14

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About This Item

Empirical Formula (Hill Notation):
C19H42NO4P
CAS Number:
77733-28-9
Molecular Weight:
379.51
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850338P-1g)
pkg of 1 × 10 g (850338P-10g)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850338P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C19H42NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-23-25(21,22)24-19-17-20(2,3)4/h5-19H2,1-4H3

InChI key

BETUMLXGYDBOLV-UHFFFAOYSA-N

General description

MAPCHO™-14 is a fos-choline-based zwitterionic detergent.
Tetradecylphosphocholine is a structural analog of myristoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification. It has been used as a helper lipid for in vitro and in vivo gene transfer, and it has been shown to have some anticancer activity.

Application

MAPCHO™-14 has been used as a supplement in extraction buffer (RIPA buffer).

Biochem/physiol Actions

Fos-choline-14 (N-tetradecylphosphocholine) is mainly used for solubilization and purification of proteins.

Packaging

20 mL Clear Glass Screw Cap Vial (850338P-1g)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (850338P-10g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line
Cook BL, et al.
Testing, 3(8), e2920-e2920 (2008)
Brian L Cook et al.
PloS one, 3(8), e2920-e2920 (2008-08-07)
In order to begin to study the structural and functional mechanisms of olfactory receptors, methods for milligram-scale purification are required. Here we demonstrate the production and expression of a synthetically engineered human olfactory receptor hOR17-4 gene in a stable tetracycline-inducible
Christoph Göbl et al.
The journal of physical chemistry. B, 114(13), 4717-4724 (2010-03-17)
The interaction with biological membranes is of functional importance for many peptides and proteins. Structural studies on such membrane-bound biomacromolecules are often carried out in solutions containing small membrane-mimetic assemblies of detergent molecules. To investigate the influence of the hydrophobic
Reinhard Zeisig et al.
Cancer gene therapy, 10(4), 302-311 (2003-04-08)
To improve liposomal gene transfer we investigated the influence of membrane-interacting alkylphospholipids (APLs) on gene transfer efficiency in vitro and in vivo using the LacZ reporter gene and the cytosine deaminase (CD) suicide gene. Liposomes were first optimized concerning the
Gregory Vernier et al.
Protein science : a publication of the Protein Society, 18(9), 1882-1895 (2009-07-18)
Proteolytically activated Protective Antigen (PA) moiety of anthrax toxin self-associates to form a heptameric ring-shaped oligomer (the prepore). Acidic pH within the endosome converts the prepore to a pore that serves as a passageway for the toxin's enzymatic moieties to
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