Key Documents

Thio-TEPA

Name: Thio-TEPA
Brand: SIGMA

Synonym(s):

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₂N₃PS

CAS Number:

52-24-4

Molecular Weight:

189.22

NACRES:

NA.85

PubChem Substance ID:

24900346

UNSPSC Code:

51102829

EC Number:

200-135-7

MDL number:

MFCD00145452

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Properties

form

solid

Quality Segment

200

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChI key

FOCVUCIESVLUNU-UHFFFAOYSA-N

Description

General description

Chemical structure: aziridine

Application

A polyfunctional alkylating agent

Biochem/physiol Actions

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division[1].

Analysis Note

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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This Item	M0440	M0503	03907
Sigma-Aldrich T6069 Thio-TEPA	Sigma-Aldrich M0440 Mitomycin C from Streptomyces caespitosus	Sigma-Aldrich M0503 Mitomycin C from Streptomyces caespitosus	Sigma-Aldrich 03907 Tioconazole
antibiotic activity spectrum neoplastics	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum fungi, yeast
mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes	mode of action cell membrane \| interferes
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
form solid	form -	form powder	form powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -
storage condition (Keep container tightly closed in a dry and well-ventilated place.)	storage condition -	storage condition -	storage condition -

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H350

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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