SML3775

Desthiobiotin-Phenol

≥98% (HPLC), peroxidase sensitive probe, powder

• Synonym(s): (4R,5S)-N-[2-(4-Hydroxyphenyl)ethyl]-5-methyl-2-oxo-4-imidazolidinehexanamide, DBP, Desthiobiotin-Tyramide, N-(4-Hydroxyphenethyl)-6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamide, d-Desthiobiotin-Phenol
• Empirical Formula (Hill Notation): C₁₈H₂₇N₃O₃
• CAS Number: 2242902-55-0
• Molecular Weight: 333.43
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Desthiobiotin-Phenol, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

A peroxidase-sensitive desthiobiotin-phenol (DBP) probe that offers more efficient recovery of DBP-labeled peptides from streptavidin beads and stronger mass spectrometry intensity of modified membrane proteins and achieves greater sensitivity for tyrosine residues detection. DBP shows a similar reactivity to the protein when it is converted to the phenoxyl radical state as biotin-phenol/biotin-tyramide (BP) in ascorbate peroxidase (APEX) proximity labeling. DBP exhibits reduced affinity to streptavidin and does not suffer from sulfur oxidation issue during the radical generation.

APEX (ascorbate peroxidase) proximity tyrosine site label, a sulfur-free Biotin-Tyramide analog that can be displaced competitively by biotin

Safety Information

• wgk: WGK 3
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable