SML3302
SNI-1
≥98% (HPLC)
Synonym(s):
1-(3,4-Dihydroxy-phenyl)-2-(1-p-tolyl-1H-tetrazol-5-ylsulfanyl)-ethanone
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About This Item
Empirical Formula (Hill Notation):
C16H14N4O3S
CAS Number:
Molecular Weight:
342.37
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=CC=C(C=C1)N2C(SCC(C3=CC(O)=C(C=C3)O)=O)=NN=N2
InChI key
MVIWFFDPSPYDKQ-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibitor of CARP-1(CCAR1)-NEMO interaction that binds to CARP-1 and potentiates chemotherapeutic effects of DNA damaging agents
SNI-1 is an inhibitor of CARP-1(CCAR1)-NEMO (NF-κB essential modulator) interaction that binds to CARP-1. SNI-1 inhibits chemotherapy-dependent canonical NF-κB signaling and attenuates secretion of the pro-inflammatory cytokines TNFα, IL-1β, and IL-8. It potentiates chemotherapeutic effects of DNA damaging agents such as Cisplatin and Adriamycin (doxorubicin) in several cancer cell lines including human triple-negative breast cancer (TNBC).
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This Item | |
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| description ≥98% (HPLC) | description NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA. |
| form powder | form - |
| assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. −196°C |
| solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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