SML3010

Belinostat

≥98% (HPLC)

• Synonym(s): (2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide, (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide, (E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide, PX 105684, PX-105684, PX105684, PXD 101, PXD-101, PXD101
• Empirical Formula (Hill Notation): C₁₅H₁₄N₂O₄S
• CAS Number: 866323-14-0
• Molecular Weight: 318.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD08064035
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [S](=O)(=O)(Nc2ccccc2)c1cc(ccc1)\C=C\C(=O)NO
• InChI: 1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
• InChI key: NCNRHFGMJRPRSK-MDZDMXLPSA-N

Description

Biochem/physiol Actions

Belinostat (PX105684; PXD101) is a potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 41/125/30/216 nM, class IIA HDAC4/7/9 = 115/67/128 nM, class IIB HDAC6 = 82 nM) with anti-cancer efficacy in vitro and in vivo.

Potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor with anti-cancer efficacy in vitro and in vivo.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H361f,H373
• pcodes: P201 - P202 - P260 - P280 - P308 + P313 - P405
• Hazard Classifications: Muta. 1B - Repr. 2 - STOT RE 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable