Unfortunately, long-term solution stability studies have not been performed on this product. Other sources suggest that stock solutions in DMSO may be stable for up to 1 year at -20°C in frozen aliquots. This information has not been validated.
SML3007
H3B-120
≥98% (HPLC)
Synonym(s):
N1-Methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-1,4-piperidinedicarboxamide
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About This Item
Empirical Formula (Hill Notation):
C19H24N4O2S
CAS Number:
Molecular Weight:
372.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1CCN(CC1)C(N(C)CC2=CC=CC=C2)=O)NC3=NC(C)=CS3
InChI
1S/C19H24N4O2S/c1-14-13-26-18(20-14)21-17(24)16-8-10-23(11-9-16)19(25)22(2)12-15-6-4-3-5-7-15/h3-7,13,16H,8-12H2,1-2H3,(H,20,21,24)
InChI key
ZEVOZXRSCSSPAO-UHFFFAOYSA-N
Biochem/physiol Actions
H3B-120 is a cell penetrant, potent and selective allosteric inhibitor of the carbamoyl phosphate synthetase 1 (CPS1) that blocks ATP hydrolysis in the first step of carbamoyl phosphate synthesis
cell penetrant, potent and selective allosteric inhibitor of the carbamoyl phosphate synthetase 1 (CPS1)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Shihua Yao et al.
Cell chemical biology, 27(3), 259-268 (2020-02-06)
Carbamoyl phosphate synthetase 1 (CPS1) catalyzes the first step in the ammonia-detoxifying urea cycle, converting ammonia to carbamoyl phosphate under physiologic conditions. In cancer, CPS1 overexpression supports pyrimidine synthesis to promote tumor growth in some cancer types, while in others
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Hello, I would like to know how to conserve the product H3B-120 - SML3007-5MG , after suspension in DMSO at the concentration 2mg/ml. Is it possible to do aliquots and keep it at -20°C? Thank you for your help
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