SML1899

SR144528

≥98% (HPLC), CB2 receptor inverse agonist, powder

• Synonym(s): 5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide, SR-144528
• Empirical Formula (Hill Notation): C₂₉H₃₄ClN₃O
• CAS Number: 192703-06-3
• Molecular Weight: 476.05
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD05662316
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: SR144528, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: C[C@]12[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H](C2)CC1
• InChI: 1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
• InChI key: SUGVYNSRNKFXQM-XRHWURSXSA-N

Description

Application

SR144528 has been used as a cannabinoid CB2 receptor antagonist:

• to study its blocking effect on the anti-dyskinetic functionality of HU-308[1]
• to study its effects on spontaneous excitatory postsynaptic currents (sEPSCs) from the globus pallidus neurons[2]
• to analyze its effect on the gastric emptying in rats[3]

Biochem/physiol Actions

SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist.

SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist. SR144528 exhibited a Ki of 0.6 nM at CB2 compared to 400 nM at the related CB1 receptor.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3