SML1857
LRE1
≥98% (HPLC)
Synonym(s):
6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine, RU-0204277
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About This Item
Empirical Formula (Hill Notation):
C12H13ClN4S
CAS Number:
Molecular Weight:
280.78
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1
InChI key
PDWZXKSZLRVSEH-UHFFFAOYSA-N
Biochem/physiol Actions
LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 μM, similar to that of KH7 and without its cellular toxicity.
Selective allosteric inhibitor of soluble adenylyl cyclase (sAC)
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: ≥20 mg/mL | solubility DMSO: 20 mg/mL, clear |
| color white to beige | color off-white to light brown | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
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