The stability of this material in solution has not been evaluated. For optimum results, stock solutions should be prepared fresh. However, external sources indicate that stock solutions prepared in DMSO, and purged with inert gas, may be stored for up to 1 year at -20°C and up to 2 years at -80°C, in working aliquots. Avoid repeated freeze/thaw cycles. This information has not been validated.
SML1682
CDN1163
≥98% (HPLC), SERCA activator, powder
Synonym(s):
4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)-benzamide
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About This Item
Empirical Formula (Hill Notation):
C20H20N2O2
CAS Number:
Molecular Weight:
320.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
CDN1163, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1
InChI
1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)
InChI key
GVGVYDCVFBGALZ-UHFFFAOYSA-N
Biochem/physiol Actions
CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. Additionally CDN1163 induces significant reduction in adipose tissue weight with no change in lean mass in ob/ob mice. CDN1163 has no effect on glucose levels or body weight in lean control mice.
CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA).
CDN1163 treatment declined the hepatic expression of genes implicated in gluconeogenesis and lipogenesis as well as attenuated endoplasmic reticulum (ER) stress response and ER stress-induced apoptosis. CDN1163 interacts with sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and enhances ER Ca2+ content.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 20 mg/mL, clear (warmed) | solubility DMSO: >5 mg/mL |
| color white to beige | color white to beige | color white to brown | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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After reconstitution in DMSO, what are the recommended storage conditions and expected stability?
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