SML1620

NGI-1

≥95% (HPLC), Asparagine (N)-linked glycoslysation inhibitor, powder

• Synonym(s): 5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide, ML414
• Empirical Formula (Hill Notation): C₁₇H₂₂N₄O₃S₂
• CAS Number: 790702-57-7
• Molecular Weight: 394.51
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Product Name: NGI-1, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C
• InChI key: QPKGRLIYJGBKJL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation.

NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation. NGI-1 inhibits the oligosaccharyltransferase, preventing the attachment to the protein. NGI-1 has been shown to induce senescence in receptor tyrosine kinase dependent tumors.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3