SML0838

PACMA 31

≥98% (HPLC)

• Synonym(s): N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
• Empirical Formula (Hill Notation): C₂₁H₂₂N₂O₆S
• CAS Number: 1401089-31-3
• Molecular Weight: 430.47
• NACRES: NA.77
• PubChem Substance ID: 329825605
• UNSPSC Code: 12352200
• MDL number: MFCD26793891
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: C#CC(N(C(C1=CC=CS1)C(NCC(OCC)=O)=O)C2=CC=C(OC)C=C2OC)=O
• InChI: 1S/C21H22N2O6S/c1-5-18(24)23(15-10-9-14(27-3)12-16(15)28-4)20(17-8-7-11-30-17)21(26)22-13-19(25)29-6-2/h1,7-12,20H,6,13H2,2-4H3,(H,22,26)
• InChI key: AHOOZADJPNUFOQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PACMA 31 is an orally bioavailable, selective inhibitor (IC₅₀ = 10 μM) of protein disulfide isomerase (PDI), an endoplasmic reticulum protein that regulates oxidative protein folding by catalyzing the breakage and reformation of disulfide bonds. PDI is upregulated in ovarian, and several other cancers. PACMA 31 dose dependently inhibits proliferation of OVCAR-8 in culture and in a tumor xenograft model.

PACMA 31 is an orally bioavailable, selective inhibitor (IC₅₀ = 10 μM) of protein disulfide isomerase (PDI).

Both in vivo and in vitro studies reveal that PACMA 31 possesses anti-tumor function, especially observed in ovarian cancer.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable