SML0802

ZLN005

≥95% (HPLC)

• Synonym(s): 2-(4-tert-Butylphenyl)-1H-benzimidazole, 2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazole
• Empirical Formula (Hill Notation): C₁₇H₁₈N₂
• CAS Number: 49671-76-3
• Molecular Weight: 250.34
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [nH]1c2c(nc1c3ccc(cc3)C(C)(C)C)cccc2
• InChI: 1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)
• InChI key: LQUNNCQSFFKSSK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ZLN005 is a transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 increased PGC-1 and downstream gene transcription in skeletal muscle, while reducing hepatic PGC-1α and gluconeogenesis genes. ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance, insulin sensitivity, hyperglycemia and dyslipidemia of diabetic db/db mice.

ZLN005 is a transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3