SML0564

PD153035 hydrochloride

≥98% (HPLC)

• Synonym(s): 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride, AG 1517, PD 153035, SU 5271, ZM 252868
• Empirical Formula (Hill Notation): C₁₆H₁₄BrN₃O₂ · HCl
• CAS Number: 183322-45-4
• Molecular Weight: 396.67
• NACRES: NA.77
• PubChem Substance ID: 329825555
• UNSPSC Code: 51111800
• MDL number: MFCD01074805
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: Cl.COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
• InChI: 1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H
• InChI key: ZJOKWAWPAPMNIM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PD153035 is an EGFR tyrosine kinase inhibitor.

PD153035 is apotent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS06,GHS05
• signalword: Danger
• hcodes: H301,H315,H318,H335
• pcodes: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable