SML0560

BRACO19 hydrochloride

≥96% (HPLC), powder, telomerase inhibitor

• Synonym(s): N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride
• Empirical Formula (Hill Notation): C₃₅H₄₃N₇O₂ · xHCl
• CAS Number: 1177798-88-7
• Molecular Weight: 593.76 (free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825553
• NACRES: NA.77
• MDL number: MFCD23380200
• Assay: ≥96% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: BRACO19 hydrochloride, ≥96% (HPLC)
• assay: ≥96% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow to brown
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1
• InChI: 1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H
• InChI key: MJAPNWJRLLDPAB-UHFFFAOYSA-N

Description

Application

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).

Biochem/physiol Actions

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

BRACO19 stabilizes G-quadruplexes; telomerase inhibitor.

Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment. BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable