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RAD51 Inhibitor B02

Name: RAD51 Inhibitor B02
Brand: SIGMA

≥98% (HPLC), RAD51 recombinase inhibitor, powder

Synonym(s):

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₇N₃O

CAS Number:

1290541-46-6

Molecular Weight:

339.39

UNSPSC Code:

12352200

PubChem Substance ID:

329825366

NACRES:

NA.77

MDL number:

MFCD03294274

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

RAD51 Inhibitor B02, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to dark brown

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4

InChI

1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+

InChI key

GEKDQXSPTHHANP-OUKQBFOZSA-N

Description

Application

RAD51 Inhibitor B02 has been used:

to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
for RAD51 inhibition in porcine embryos
as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)

Biochem/physiol Actions

B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.

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This Item	SML1085	SML1685	SML2733
Sigma-Aldrich SML0364 RAD51 Inhibitor B02	Sigma-Aldrich SML1085 Retro-2	Sigma-Aldrich SML1685 Ribocil-C	Sigma-Aldrich SML2733 RLA8
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: ≥5 mg/mL	solubility DMSO: 10 mg/mL, clear (warmed)	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
color white to dark brown	color white to beige	color white to beige	color white to beige

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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