SML0276

BD 1063 dihydrochloride

≥98% (HPLC)

• Synonym(s): 1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride, BD1063 dihydrochloride
• Empirical Formula (Hill Notation): C₁₃H₁₈Cl₂N₂ · 2HCl
• CAS Number: 206996-13-6
• Molecular Weight: 346.12
• NACRES: NA.77
• PubChem Substance ID: 329825284
• UNSPSC Code: 12352200
• MDL number: MFCD00792740
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: >15 mg/mL
• storage temp.: room temp
• SMILES string: Cl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2
• InChI: 1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
• InChI key: NXFDBTLQOARIMH-UHFFFAOYSA-N

Description

Application

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:

• to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
• in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
• to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

Biochem/physiol Actions

BD 1063 is a potent sigma(1) receptor antagonist.

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

Other Notes

air sensitive

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable