SML0033

Itopride hydrochloride

≥98% (HPLC), dopamine D2-receptor antagonist, powder

• Synonym(s): N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride, N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride
• Empirical Formula (Hill Notation): C₂₀H₂₆N₂O₄ ·HCl
• CAS Number: 122892-31-3
• Molecular Weight: 394.89
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825103
• NACRES: NA.77
• MDL number: MFCD00881710
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Itopride hydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥48 mg/mL
• originator: Abbott
• storage temp.: 2-8°C
• SMILES string: Cl.COc1ccc(cc1OC)C(=O)NCc2ccc(OCCN(C)C)cc2
• InChI: 1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
• InChI key: ZTOUXLLIPWWHSR-UHFFFAOYSA-N

Description

General description

Itopride hydrochloride is a new prokinetic drug.

Biochem/physiol Actions

Antagonist of dopamine D2-receptor with anticholinesterase activity.

Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.

Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable