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SCP0004

γ Secretase Inhibitor

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C26H41N3O5
Molecular Weight:
475.62
NACRES:
NA.32
UNSPSC Code:
12352200
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

General description

Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.

Application

γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.

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This Item
SCP0025565761565770
γ Secretase Inhibitor ≥95% (HPLC)

Sigma-Aldrich

SCP0004

γ Secretase Inhibitor

APP γ Secretase Inhibitor

Sigma-Aldrich

SCP0025

APP γ Secretase Inhibitor

γ-Secretase Inhibitor IV The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Sigma-Aldrich

565761

γ-Secretase Inhibitor IV

γ-Secretase Inhibitor IX Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC50 = 115 nM, Aβ42 IC50 = 200 nM).

Sigma-Aldrich

565770

γ-Secretase Inhibitor IX

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

lyophilized

form

lyophilized

form

lyophilized solid

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

composition

Peptide Content, ≥85%

composition

Peptide Content, ≥75%

composition

-

composition

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Questions

  1. What are the reconstitution instructions for this compound? I checked the SDS, COA, and spec sheet. Also what is the CAS#?

    1 answer

    1. The solubility of this product is in DMSO at 1 mg/ml or higher.

      In biological experiments, water is the most preferred solvent. However, several organic compounds are either not soluble in water or degrade rapidly in the presence of moisture. If DMSO is a recommended solvent, it is best to use a fresh stock bottle that is deemed free of any moisture. Any contaminating moisture may accelerate the degradation of the compound in question or may render it insoluble. It is best to make the initial serial dilutions only in DMSO and then add the final diluted sample to your buffer or the incubation medium. The final concentration of DMSO in vivo should not exceed more than 0.1 %.

      Please see the general information about the use of inhibitors in animals and these data sheets from other γ-Secretase Inhibitors from Calbiochem, which may be useful:
      http://www.emdmillipore.com/product/-Secretase-Inhibitor-I-Calbiochem,EMD_BIO-565750#anchor_PDS
      http://www.emdmillipore.com/product/-Secretase-Inhibitor-XX-CAS-209984-56-5-Calbiochem,EMD_BIO-565789#anchor_PDS

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