Key Documents

Prednisolone

Name: Prednisolone
Brand: SIGMA

≥99% (HPLC), powder, glucocorticoid

Synonym(s):

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₈O₅

CAS Number:

50-24-8

Molecular Weight:

360.44

NACRES:

NA.77

PubChem Substance ID:

24898725

UNSPSC Code:

12352200

EC Number:

200-021-7

MDL number:

MFCD00003649

Beilstein/REAXYS Number:

1354103

Assay:

≥99%

Form:

powder

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Properties

Product Name

Prednisolone, ≥99%

biological source

synthetic (organic)

Quality Segment

200

sterility

non-sterile

assay

≥99%

form

powder

mp

240 °C (dec.) (lit.)

solubility

chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow

originator

Johnson & Johnson

shipped in

ambient

storage temp.

room temp

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

OIGNJSKKLXVSLS-VWUMJDOOSA-N

Gene Information

human ... AR(367), ESR1(2099), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Nr3c1(14815)
rat ... Ar(24208)

Description

General description

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

Application

Prednisolone has been used for the Δ¹-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

Biochem/physiol Actions

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Analysis Note

Actual content given on label

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This Item	1555005	P2700000	PHR1043
Sigma-Aldrich P6004 Prednisolone	USP 1555005 Prednisolone	P2700000 Prednisolone	Supelco PHR1043 Prednisolone
description ≥99%	description United States Pharmacopeia (USP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard	description Pharmaceutical Secondary Standard; Certified Reference Material
form powder	form -	form -	form -
assay ≥99%	assay -	assay -	assay -
Quality Level 200	Quality Level -	Quality Level -	Quality Level 300
storage temp. room temp	storage temp. 2-8°C	storage temp. -	storage temp. 2-30°C
solubility chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow	solubility -	solubility -	solubility -
originator Johnson & Johnson	originator -	originator -	originator -

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Explore all of our products under Prednisolone

pictograms

GHS08

signalword

Danger

hcodes

H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

ppe

dust mask type N95 (US), Eyeshields, Gloves

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