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N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride

Name: N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Brand: SIGMA

≥97% (GC), MAO-A inhibitor, powder

Synonym(s):

Clorgyline

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₅Cl₂NO · HCl

CAS Number:

17780-75-5

Molecular Weight:

308.63

NACRES:

NA.77

PubChem Substance ID:

24278179

UNSPSC Code:

12352116

EC Number:

241-760-5

MDL number:

MFCD00052012

Assay:

≥97% (GC)

Form:

powder

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Properties

Product Name

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride, ≥97% (GC)

Quality Segment

100

assay

≥97% (GC)

form

powder

solubility

DMSO: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C

InChI

1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H

InChI key

BBAZDLONIUABKI-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128)
rat ... Maoa(29253), Maob(25750)

Description

Application

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:

in MAO-A biochemical assay[1]
to study its effects on the transit of serotonin (5-HT) in the human placenta explants[2]
to study its effects on human prostate cancer cells[3]

Biochem/physiol Actions

MAO-A inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	P8511	E2895	A3085
Sigma-Aldrich M3778 N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride	Sigma-Aldrich P8511 trans-2-Phenylcyclopropylamine hydrochloride	Sigma-Aldrich E2895 (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide	Sigma-Aldrich A3085 5-(N-Ethyl-N-isopropyl)amiloride
form powder	form powder	form powder	form powder
assay ≥97% (GC)	assay ≥97% (TLC)	assay ≥98%	assay ≥98% (TLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow	solubility ethanol: 50 mg/mL, clear to slightly hazy	solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow	solubility methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
Gene Information human ... MAOA(4128) rat ... Maoa(29253), Maob(25750)	Gene Information human ... MAOA(4128), MAOB(4129)	Gene Information -	Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)

pictograms

GHS06

signalword

Danger

hcodes

H301,H312 + H332

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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