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Lipopolysaccharides from Salmonella enterica serotype typhimurium

Name: Lipopolysaccharides from <I>Salmonella enterica</I> serotype typhimurium
Brand: SIGMA

purified by gel-filtration chromatography

Synonym(s):

LPS

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About This Item

UNSPSC Code:

12352201

NACRES:

NA.25

MDL number:

MFCD00164404

Pricing and availability is not currently available.

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Properties

biological source

Salmonella enterica (Serotype typhimurium)

Quality Level

200

form

lyophilized powder

purified by

gel-filtration chromatography

impurities

<1% Protein

color

white to faint yellow

solubility

water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow

shipped in

ambient

storage temp.

2-8°C

Description

General description

This product is extracted from Salmonella typhimurium and purified by gel filtration. The source strain is ATCC 7823.

Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Biochem/physiol Actions

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Preparation Note

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 ^oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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This Item	L7261	L6511	L2387
Sigma-Aldrich L2262 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L7261 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L6511 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L2387 Lipopolysaccharides from Salmonella typhosa
biological source Salmonella enterica (Serotype typhimurium)	biological source Salmonella enterica (Serotype typhimurium)	biological source Salmonella enterica (Serotype typhimurium)	biological source bacterial (Salmonella typhosa)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
solubility water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow	solubility water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow	solubility water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow	solubility water: soluble
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
impurities <1% Protein	impurities 1-10% Protein (Lowry)	impurities <3% Protein (Lowry)	impurities <1% Protein

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells.

Rossella Paolillo et al.

International immunopharmacology, 9(11), 1265-1271 (2009-08-04)

Probiotics, defined as live microbial food supplements which improve the health of the host, have obtained increasing medical importance. In the intestine they may prevent the overgrowth of pathogenic bacteria, increase the resistance of the gut to invasion by pathogens

Green tea extract attenuates LPS-induced retinal inflammation in rats.

Jia Lin Ren et al.

Scientific reports, 8(1), 429-429 (2018-01-13)

Inflammation is in a wide spectrum of retinal diseases, causing irreversible blindness and visual impairment. We have previously demonstrated that Green Tea Extract (GTE) is a potent anti-inflammatory agent for anterior uveitis. Here we investigated the anti-inflammatory effect of GTE

Salmonella Typhimurium exploits inflammation to its own advantage in piglets.

Barbara Chirullo et al.

Frontiers in microbiology, 6, 985-985 (2015-10-07)

Salmonella Typhimurium (S. Typhimurium) is responsible for foodborne zoonotic infections that, in humans, induce self-limiting gastroenteritis. The aim of this study was to evaluate whether the wild-type strain S. Typhimurium (STM14028) is able to exploit inflammation fostering an active infection.

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Global Trade Item Number

SKU	GTIN
L2262-5MG	04061833272114
L2262-25MG	04061833949962

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